Effect of plant stages on analgesic and anti inflammatory activity of the leaves of Tectona grandis

The methanolic extracts of the frontal and mature leaves of Tectona grandis were comparatively evaluated for their analgesic and anti inflammatory activity. The analgesic and anti inflammatory activities were evaluated using the Eddy’s hot plate and Carrageenan induced paw edema models in rats respectively. The results of the analgesic activity have revealed that the frontal leaves and the mature leaves of Tectona grandis have showed significant analgesic activity. The analgesic activity of the high dose of the mature leaves (500 mg/kg body weight) was almost equal to the analgesic activity caused by the low dose (250 mg/kg body weight) of the frontal leaves extract at 15, 30, 60 and 120 min. The results of the anti inflammatory activity have shown that the frontal leaf extract when administered at a dose of 250 mg/kg body weight had significant activity after 15 min which was comparable to the standard. However the mature leaves extract did not show any significant activity at the same dose.